Metabolism Ketamine is metabolized by means of N-dealkylation to your Lively metabolite norketamine generally by CYP2B6 and CYP3A4 and to a lesser extent by other CYP enzymes. Norketamine undergoes hydroxylation from the cyclohexone ring to form hydroxynorketamine compounds by using CYP-dependent pathways, which are conjugated with glucuronic acid